|
KMID : 0380020100250050449
|
|
Korean Journal of Biotechnology and Bioengineering
2010 Volume.25 No. 5 p.449 ~ p.452
|
|
|
Monitoring of the Optical Purity for Levothyroxine Sodium in Pharmaceuticals Using Crown Ether Derived Chiral Columns
|
|
Jeon So-Hee
Lee Won-Jae
|
|
|
Abstract
|
|
|
|
L-Thyroxine possessing a chiral center, the naturally occurring thyroid hormone has been used for the treatment of thyroid dysfunctions and marketed as levothyroxine (L-thyroxine) sodium salt. In this study, after extraction of levothyroxine tablet as a pre-treatment process, direct enantiomer separation of thyroxine on crown ether derived chiral columns for determination of optical purity was performed using reversed mobile phase with acid additive. The chromatographic method developed in this study was applied in the determination of optical purity of several current domestic and foreign commercialized levothyroxine tablets. Optical purity values of these commercialized L-thyroxine sodium tablets except one were higher than 99 percents
|
|
|
KEYWORD
|
|
|
Enantiomer separation, Thyroxine, Chiral column, Optical purity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|